IMMUNOCHEMICAL RELATION OF BENCE-JONES PROTEINS TO NORMAL SERUM PROTEINS
نویسندگان
چکیده
منابع مشابه
Metabolism of Bence Jones Proteins.
Bence Jones proteins are molecules of about 40,000 mol wt present in the urine of many patients with plasma cell malignancy. These microglobulins, which are synthesized in plasma-cell tumors (1, 2), share many immunochemical and physicochemical features with the larger 6.6 S y-globulins. That Bence Jones proteins are similar to or identical with components of the larger y-globulins has been sug...
متن کاملThe Nature of Bence-jones Proteins
The chemical relations among Bence-Jones proteins, myeloma proteins, and normal gamma-globulins have been investigated by a variety of means. Starch gel electrophoresis in 8 M urea of reduced alkylated Bence-Jones proteins yielded patterns of bands corresponding to those of the light (L) polypeptide chains of the dissociated myeloma protein from the same patient. One instance in which this corr...
متن کاملHuman Antibody Reacting with Bence Jones Proteins
The light (L) polypeptide chains of the human T-globulins carry antigenic determinants designated as group 1 or 2 (1-3). Allotypic determinants designated InV have been found in association with the L chains of 3,,-globulin (4). Natural ly occurring human ant ibody directed toward L chain determinants has been described in detail only for the InV antigens (5). The present studies utilize human ...
متن کاملImmunoglobulin D myeloma and amyloidosis: immunochemical and structural studies of Bence Jones and amyloid fibrillar proteins.
Urinary Bence Jones protein and amyloid fibril protein isolated from the subcutaneous tissue of a patient with IgD myeloma and associated amyloidosis were subjected to physicochemical and immunochemical identification. Peptide maps and amino-terminal tetrapeptide composition obtained from the two proteins were comparable. Immunochemical cross-reactivity between the two proteins, with other lamb...
متن کاملNormal counterparts to Bence-Jones proteins: free L polypeptide chains of human gamma-globulin.
Bence-Jones proteins are commonly found in patients with multiple myeloma and have been defined classically' as abnormal urinary proteins that have characteristic thermosolubility properties. Structural studies2 have shown that BenceJones proteins are similar or identical to the light (L) polypeptide chains isolated from the myeloma globulin of the same patient. Taken in conjunction with the re...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1955
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)52287-6